Immunotherapy has recently become a promising cancer therapy with extensive applications of immune checkpoint inhibitors (ICIs).However, pancreatic ductal adenocarcinoma (PDAC) appears to be unresponsive to immunotherapy due to the Dinner Bowls immunosuppressive microenvironment.Recent studies showed that cancer stem cell marker DCLK1 promoted the
The purpose of this paper is two-fold.One is to clarify the concept of gravity in international trade flows.The other is to measure the strength of gravity in international trade flows in a way that is consistent with a well-defined concept of gravity.This paper shows that the widely accepted belief that specialization is the source of gravity is n
Abstract Background Xenograft samples used to test anti-cancer drug efficacies and toxicities in vivo contain an unknown mix of ULTRA BALM mouse and human cells.Evaluation of drug activity can be confounded by samples containing large amounts of contaminating mouse tissue.We have developed a real-time quantitative polymerase chain reaction (qPCR) a
In the era of coal power station phase-out, natural gas fired combined cycle will drive the energy transition towards sustainable power generation.In a panorama of strong requirement for grid flexibility and non-dispatchable renewable penetration, the survival of a thermal power plant is strictly linked with operating successfully in compensating t